NASA Spaceline Current Awareness List # 959 July 23, 2021 (Space Life Sciences Research Results)



NASA Spaceline Current Awareness List # 959 July 23, 2021 (Space Life Sciences Research Results)

Status report of: Spaceline
Posted: Friday July 23 2021

Articles supported by NASA:


Bailey SM, Luxton JJ, McKenna MJ, Taylor LE, George KA, Jhavar SG, Swanson GP.

Ad Astra – Telomeres in space!

Int J Radiat Biol. 2021 16: 1-26. Meet again. Online ahead of print.

PI: SM Bailey

To note: ISS results. Excerpt from the abstract: “Here I review the results of our NASA twin study and telomere investigations, highlighting the potential mechanistic roles of chronic space radiation exposure in telomere length changes. and the persistent responses to DNA damage associated with long duration spaceflight. This article can be obtained online at no cost.

Impact factor of the journal: 2,368

Funding: “Astronaut studies were supported by NASA: NNX14AH51G [all Twins Study principal investigators (PIs)]; NNX14AB02G and 80NSSC19K0434 (SMB). Funding for the prostate cancer studies was provided by a philanthropic donation to the Baylor Scott & White Central Texas Foundation, Temple, Texas, USA, and the Colorado Office of Economic Development and International Trade (OEDIT) Advanced Industry (AI) Bioscience Proof of Concept Awards Program (POC), Colorado State University (CSU) Ventures. The Graduate Scholarships awarded by the CSU Research and Academic Excellence Program (PRSE) and PRSE in Cancer Biology and Comparative Oncology (CB&CO) to support quantitative studies in Cellular and Molecular Biology (qCMB) are also appreciated. “


Gurubhagavatula I, Barger LK, Barnes CM, Basner M, Boivin DB, Dawson D, Drake CL, Flynn-Evans EE, Mysliwiec V, Patterson PD, Reid KJ, Samuels C, Shattuck NL, Kazmi U, Carandang G, Heald JL, Van Dongen HPA.

Guiding Principles for Determining Shift Lengths and Addressing the Effects of Shift Lengths on Performance, Safety and Health.

To sleep. July 15, 2021; zsab161. Online ahead of print.

To note: This article can be obtained online at no cost.

Impact factor of the journal: 4.805

Funding: EE Flynn-Evans is affiliated with the NASA Ames Research Center.


Other interesting documents:


Mitrikas VG.

[Some aspects of the radiation exposure of cosmonauts traversing the Earth’s magnetosphere.]

Aviakosm Ekolog Med. 2021; 55 (3): 51-56. Russian.

To note: Extract from the summary: “The dose load of representative body organs of the cosmonaut beyond the Earth’s magnetosphere was calculated for various scenarios of departure from a reference orbit in space vehicles of different design. Calculation of the contribution to equivalent doses of protons and electrons from Earth’s radiation belts and galactic cosmic rays (GCRs) have demonstrated that, regardless of vehicle design, during solar minimum and increasing activity, the equivalent dose does not exceed the limit established for a single exposure is 150 mSv. However, the radiation exposure can sometimes vary depending on the trajectory of the crossing. “


Tzetlin VV, Bersenev EY, Stepanova GP, Degterenkova NV, Anikeev DAA.

[Monitoring of the effects of isolation factors on human physiological functions within the SIRIUS-19 project.]

Aviakosm Ekolog Med. 2021; 55 (3): 36-44. Russian.

To note: Results of the analog isolation and containment mission of SIRIUS 19. Extract from the summary: “The article presents the results of the examination of 6 volunteers (3 men and 3 women) in a 120-day isolation study aimed at to simulate a mission to the moon. “


Ilyin VK, Komissarova DV, Usanova NА, Morozova YA.

[Investigations of microflora from professional test-subjects and volunteers for isolation studies of up to 20 days in duration.]

Aviakosm Ekolog Med. 2021; 55 (3): 57-61. Russian.

To note: Excerpt from the abstract: “Microbiocenosis in the upper respiratory tract and intestine was studied in experienced test subjects who may have possibly adapted to stress in chamber studies lasting 8 at 10 days faster than beginners. The eubiotic index was used to assess positive and negative changes in the microbiota. The gut microflora in experienced subjects was found to be more plastic and adapted much faster compared to to inexperienced counterparts. In both groups, the composition of the microbiota was slightly compromised at the end of the acute adaptation and then stabilized. “


Nakajima S, Nagata M, Ikehata A.

Mechanism to improve the growth of mung bean seedlings under simulated microgravity.

npj Microgravity. July 15, 2021; 7 (1): 26.

To note: A clinostat was used in this study. This article can be obtained online at no cost.


Tyrina GЕА, Bobyleva PI, Andreeva ER, Buravkova LB.

[Strome-dependent expansion of hematopoietic precursors during 7-day modeling of the effects of microgravity.]

Aviakosm Ekolog Med. 2021; 55 (3): 28-35. Russian.

To note: The microgravity modeling method was not identified in the English summary. Abstract excerpt: “In this investigation, we used several optimized mesenchymal stromal cell (MSC) and hematopoietic stem and progenitor cell (HSPC) co-culture models to analyze HSPC suspension fractions after 7-day modeling. effects of microgravity. “


MacLean MK, Ferris DP.

Human muscle activity and lower limb biomechanics of surface walking at different levels of reduced gravity and simulated walking speeds.

PLoS One. Jul 14, 2021; 16 (7): e0253467.

To note: A low cost body weight support system was used in this study. This article can be obtained online at no cost.


Pashchenko PS, Sukhoterin AF, Shapovalov PA.

[Structural and functional manifestations of acute and chronic gravitational stress in the adrenal.]

Aviakosm Ekolog Med. 2021; 55 (3): 66-73. Russian.


Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N.

Mechanical load regulates bone growth via the periosteal osteocrine.

Cell Rep. 2021 Jul 13; 36 (2): 109380.

To note: Study of unloading of the hind limbs. This article can be obtained online at no cost.


Ayoub R, Lau K, Yuen N, Fernandes D, Elder M, Yeung J, Wong SC, Nieman BJ.

Spatio-temporal mapping of early volume loss in mouse brain after cranial irradiation.

Radiat Res. July 16, 2021. Online ahead of print.


Shafirkin AV, Grigoriev YG, Ushakov IB, Shurshakov VA.

[Biological effectiveness of fast neutrons and accelerated multicharged ions for derivation of a new dependence of space radiation quality coefficients on linear energy transfer.]

Aviakosm Ekolog Med. 2021; 55 (3): 5-15. Russian.

To note: Extract from the abstract: “The authors review recent experimental data on the relative biological efficiency (RBE) of low absorbed doses (0.01 to 0.5 Gy) of fast neutrons and accelerated multicharged ions currently accepted as career limits. for cosmonauts from the point of view of mitigating the risks of late effects. . “


Tabocchini MA.

A forty-year journey from “classical” biophysics and radiobiology to hadrontherapy, space radiation and underground radiobiology at low dose rate.

Int J Radiat Biol. 2021 Jul 14; 1-12. Meet again. Online ahead of print.


Parihar VK, Syage A, Flores L, Lilagan A, Allen BD, Angulo MC, Song J, Smith SM, Arechavala RJ, Giedzinski E, Limoli CL.

The inverse agonist of the cannabinoid receptor 1 AM251 improves cognitive impairment induced by radiation.

Front cell neurosci. Jun 28, 2021; 15: 668286.

To note: This article can be obtained online at no cost.


Satyamitra MM, Cassatt DR, Taliaferro LP.

A polypharmacy approach to alleviate acute radiation syndrome (ARS).

Radiat Res. July 16, 2021. Online ahead of print.


Wang Q, Wang Y, Du L, Xu C, Liu Y, Liu Q, Fan S.

Quantitative proteomic analysis of the effects of melatonin treatment for mice with small intradiation induced estinal damage.

Int J Radiat Biol. July 15, 2021; 1-26. Online ahead of print.


Fernandez-Gonzalo R, McDonnell AC, Simpson EJ, Macdonald IA, Rullman E, Mekjavic IB.

Substantial and reproducible individual variability in skeletal muscle results in the Planica cross-designed bed rest program.

Physiol before. Jul 16, 2021; 12: 1101.


Richardson MES, Brown D, Honoré D, Labossière A.

The fragmented day-night cycle induces a lengthening of the period, a decrease in anxiety and anhedonia in male mice.

Behav Brain Res. September 10, 2021; 413: 113453.


Schastlivtseva DV, Kalmanov AS, Kotrovskaya TI, Bubeev YA.

[Individual and typological characteristics of operator’s EEG reactions to time deviations in the work/rest cycle.]

Aviakosm Ekolog Med. 2021; 55 (3): 45-50. Russian.


Weenink RP, Wingelaar TT.

The circulatory effects of increased hydrostatic pressure due to submersion and submersion.

Physiol before. Jul 19, 2021; 12: 1157.


Bubeev YA, Usov VM, Kryuchkov BI, Syrkin LD, Mikhaylyuk MV.

[Operator’s spatial orientation ability during control of remotely-piloted aircraft in virtual reality.]

Aviakosm Ekolog Med. 2021; 55 (3): 16-27. Russian.

To note: Extract from the abstract: “The article analyzes the approaches used in cognitive science to explore the imagination of 2D and 3D virtual scenes and thus gain insight into the psychological aspects of spatial orientation.”


Soldatov PE, Shulaguin YA, Tyurin-Kuzmin АY, Dyachenko AI.

[Endurance of hypoxic hypoxia after preliminary breathing of normoxic mixtures containing argon or krypton.]

Aviakosm Ekolog Med. 2021; 55 (3): 74-80. Russian.

// to finish //

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